S13 Pharmacokinetics and pharmacodynamics of antimicrobials in critically ill patients with lower respiratory tract infections. are ‘one size fits all’ doses appropriate?
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چکیده
منابع مشابه
Population pharmacokinetics and pharmacodynamics of sitafloxacin in patients with community-acquired respiratory tract infections
Garenoxacin (T-3811ME, BMS-284756) is a novel, broad-spectrum des-F(6) quinolone currently under study for the treatment of community-acquired respiratory tract infections. This analysis assessed garenoxacin population pharmacokinetics and exposure-response relationships for safety (adverse effects [AE]) and antimicrobial activity (clinical cure and bacteriologic eradication of Streptococcus pn...
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586 www.pccmjournal.org June 2016 • Volume 17 • Number 6 respiratory sample. The most commonly identified viruses are rhinovirus, human bocavirus, human metapneumovirus, and respiratory syncytial virus (2). Among physicians, there is a bit of confusion about the preanalytical procedure to obtain a suitable sample and the available diagnostic tests. In a recent issue of Pediatric Critical Care M...
متن کاملOne size fits all
Teachers are increasingly being drawn from the lower parts of the general ability distribution, but it is not clear how this affects student achievement. We track the position of entering teachers in population-wide cognitive and non-cognitive ability distributions using school grades and draft records from Swedish registers. The impact on student achievement caused by the position of teachers ...
متن کاملOptimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?
INTRODUCTION The pharmacokinetic/pharmacodynamic index determining β-lactam activity is the percentage of the dosing interval (%T) during which their free serum concentration remains above a critical threshold over the minimum inhibitory concentration (MIC). Regrettably, neither the value of %T nor that of the threshold are clearly defined for critically-ill patients. Areas covered: We review a...
متن کاملPharmacokinetics and pharmacodynamics of antimicrobials.
Antibiotics are some of our most commonly used drugs. Until recently, little has been known about how to optimize administration of these agents. Unfortunately, the rate of discovery of new antibiotics has been declining, coincident with the explosion in the number of multidrug-resistant organisms in both the community and hospital environments. This development makes the identification of opti...
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ژورنال
عنوان ژورنال: Thorax
سال: 2016
ISSN: 0040-6376,1468-3296
DOI: 10.1136/thoraxjnl-2016-209333.19